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KMID : 0616120060370030206
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Korean Journal of Pharmacognosy
2006 Volume.37 No. 3 p.206 ~ p.211
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Inhibitory Effects of the SEed Extract of Myristicae Semon on the Proliferation of Human Tumor Cell Lines (Ⅱ)
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Lee Jung-Won
Choi Yeon-Hee
Yoo Mi-Young
Choi Sang-Un
Hong Kyung-Sik
Lee Byung-Hoi
Yon Gyu-Hwan
Kim Young-Sup
Kim Young-Kyoon
Ryu Shi-Yong
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Abstract
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The methanol extract from seed of Myristica fragrans (Myristicaceae) demonstrated a potent inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (overy), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon) in vitro. By the continuous effort to purify the active components responsible for the anti-proliferative effect on tumor cell lines, we have isolated eleven kinds of lignan components, i.e., safrole (1), machilin A (2), licarin B (3), macelignan (4), meso-dihydroguariaretic acid (5), myristargenol A (6), methoxyeugenol (7), machilin F (8), licarin A (9), nectandrin B (10), and 2-(4-allyl-2,6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)propan-l-ol (11), together with a novel furan fatty acid, (E)-3-(3-methyl-5-pentylfuran-2-yl) acrylic acid (12) from seed extract of M.fragrans. Chemical structures of the isolated components (1 - 12) were established by the aid of NMR spectroscopic analyses, i.e., COSY, HMQC and HMBC. Each of the isolates demonstrated a potent inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (overy), SK-MEL-2 (melanoma) and HCT-15 (colon) in vitro.
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KEYWORD
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Myristica fragrans, Myristicaceae, anti-proliferation, lignan
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